Delivery Research Theme
The strategic mission of the Delivery Theme is to overcome the challenge of transporting therapeutic agents across the blood-brain barrier (BBB) to treat neurological diseases.
We will screen and validate new delivery vectors, beginning with an rAAV capsid library screened specifically to address the challenge of delivering therapies developed by the Brain Theme to key regions like the cortex and striatum.
Research projects
Delivering across the BBB
Generating and testing vectors that can cross the blood-brain barrier
Theme publications
Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense Oligonucleotides
Team
Amarjit Bhomra
Operations Manager, Wood Group, University of Oxford
Emily Castells
Research Assistant, University of Oxford
Professor Deborah Gill
MRC CoRE TG Research Culture Lead
Professor of Gene Medicine
Head of Nuffield Department of Clinical Laboratory Sciences, University of Oxford
Dr Dhanu Gupta
MRC CoRE Delivery Theme Co-Lead
Senior Postdoctoral Researcher, University of Oxford
Dr Jakob Hansen Haldrup
Emily Haughton
DPhil student, University of Oxford
Dr Alyssa Hill
MRC CoRE TG Delivery Theme Co-Lead
Group Leader - Oligo Biology Drug Development, University of Oxford
Brian Hotchkiss
Chief Business Officer
Professor Stephen Hyde
MRC CoRE TG Delivery Theme Lead
Professor of Molecular Therapy, University of Oxford
Abinaya Ramesh
Elena Tybulewicz
DPhil Student, University of Oxford
Dr Zvonimir Vrselja
CEO, Bexorg
Dr Paul Wes
Vice President, Bexorg
Dongnan (Christina) Yan
DPhil student, University of Oxford