Resources for researchers
The MRC CoRE in Therapeutic Genomics is building a shared set of tools and resources to help researchers develop genetic medicines more quickly. This includes technologies, software, datasets, protocols and links to resources developed within the CoRE and by the wider research community. The collection will grow as the programme develops, so this page is intended to be a useful starting point for finding tools, exploring existing work and connecting with resources that can support your research.
Our internal website contains even more resources for you to explore (requires SSO login).
Key technologies
The CoRE is seeking to build a flexible toolkit, so this list will grow and change over time. Our current tools include:
- ASOs and Oligos (Antisense Oligonucleotides and Oligonucleotides)
- CRISPR
- Endosomal Escape Vehicle (EEVs)
- Lentivirus
- LNPs (Lipid Nanoparticles)
Tools made or used by the MRC CoRE TG
Code from James Davies lab
ASO Atlas by Barney Hill
OligoAI by Barney Hill
Genevar courtesy of the Wellcome Sanger Institute - platform of database and web services designed for data integration, analysis and visualization of SNP-gene associations in eQTL (expression quantitative trait loci) studies.
OligoAI - This tool predicts the efficacy of RNase H1-mediated antisense oligonucleotides (ASOs) based on their sequence and chemical modifications using the OligoAI deep learning model.
N1C gene registry - learn about what is already happening and join the effort
N1C Variant Guidelines and tools - one-stop shop for useful community guidelines
BrainVar - catalogue of paired whole-genome sequencing and bulk-tissue RNA-sequencing for human brain
N1C Variant Eligibility Calculator - eligibility assessment of pathogenic variants to antisense oligonucleotide treatments
RareMap - developed by LifeArc and Rare Disease Research UK, Raremap is a new directory bringing together organisations from across the rare disease landscape, making it easier to identify potential collaborators, patient organisations, funders, and others working in the field.