Resources for researchers

Key technologies

What are the key technologies used by the MRC CoRE?

The CoRE is seeking to build a flexible toolkit, so this list will grow and change over time. Our current tools include:

ASOs and Oligos (Antisense Oligonucleotides and Oligonucleotides)
CRISPR
Endosomal Escape Vehicle (EEVs)
Lentivirus
LNPs (Lipid Nanoparticles)

Tools made or used by the MRC CoRE TG

Software repositories

Code from James Davies lab

ASO Atlas by Barney Hill

OligoAI by Barney Hill

Genevar courtesy of the Wellcome Sanger Institute - platform of database and web services designed for data integration, analysis and visualization of SNP-gene associations in eQTL (expression quantitative trait loci) studies.

Other resources

OligoAI - This tool predicts the efficacy of RNase H1-mediated antisense oligonucleotides (ASOs) based on their sequence and chemical modifications using the OligoAI deep learning model.

N1C gene registry - learn about what is already happening and join the effort

N1C Variant Guidelines and tools - one-stop shop for useful community guidelines

BrainVar - catalogue of paired whole-genome sequencing and bulk-tissue RNA-sequencing for human brain

N1C Variant Eligibility Calculator - eligibility assessment of pathogenic variants to antisense oligonucleotide treatments