Genomics Research Theme
The Genomics Theme is the analytical engine of the MRC CoRE, providing a centralised, CoRE-wide toolkit and data framework.
The work includes two major strands:
First, to create decision-support tools and computational models to guide the therapeutic development efforts of the Blood, Brain, and Eye themes.
Second, to identify patients and genetic variants amenable to nucleic acid therapies - working closely with our PPIE Manager to develop effective and ethical communication with patients.
Our strategy is to 'plug into' and extend the established frameworks of key international partners, such as the N=1 Collaborative (N1C), rather than reinventing existing systems, ensuring that all CoRE research is grounded in robust, data-driven, and globally aligned approaches.
Research projects
MedicineMatcher
Jenny/Stephan/Nicky - what is a pithy summary?
Health Economics
Who can afford these treatments?
Identify and contact patients
Finding patients when we learn more about how to treat their conditions
Automated assessment
How much can we tell about a particular variant
GeneSYS
Pulling together all the available information on editing
GeneDB
Pulling together all the available information on genes
OligoAI
Learning everything we can from the available literature
Automated cell culture and screening at scale
Using the CellXpress.ai platform for faster and more standardised testing of potential therapies
Theme publications
Personalized CRISPR therapies could soon reach thousands — here’s how
Team
Professor Nadav Ahituv
MRC CoRE TG Site Lead, UCSF
Director for the Institute for Human Genetics at the University of California, San Francisco
Coline Arnould
EMBO Postdoctoral Fellow
Izzy Barraclough
Personal Assitant to Stephan Sanders, University of Oxford
Alex Blakes
Postdoctoral researcher
Dani Breitinger-Blatt
Programme Manager, University of Oxford
Carme Camps
Postdoctoral Researcher
Emily Castells
Research Assistant, University of Oxford
Peggy Cheung
Executive Assistant and Project Coordinator for the Oxford BRC Genetics Theme
Ruebena Dawes
Postdoctoral Bioinformatician
Chengyu Deng
Postdoctoral Researcher
Prasun Dutta
Senior Bioinformatician
Lino Ferreira
Post-Doctoral Researcher
Sarah Fong
Postdoctoral Scholar, CIRM Fellow
Jonny Gondzic
DPhil student
Michael (Mike) Griffiths
Data manager
Tamar Grossman
Co-Founder & Chief Executive Officer @ La Jolla Labs Inc.
Mona Hashim
Research Assistant
Barney Hill
DPhil Student, University of Oxford
Belusochi Joe-Ikechebelu
Research Assistant
Pamela Kaisaki
Postdoctoral Researcher
Yesim Kesim
Postdoctoral Researcher
Soo-Whee Kim
Postdoctoral Research Associate
Yujin Kim
Postdoctoral Researcher
Benny (Beniamin) Krupkin
PhD Student
Deb Lancaster
Executive Director Scientific Partnership, Genomics England
Marlen Lauffer
Senior Researcher, Dutch Center for RNA Therapeutics | Co-Lead, Patient Identification workgroup, N1C.
Marina Luchner
DPhil Student
Frederick McElwee
Researcher in Health Economics
Anthony Mcguigan
DPhil Student, University of Oxford
Liz Morrell
Senior Researcher
Dianne Newbury
Staff Scientist, University of Oxford
Yang-Kai Ng
DPhil student
Nicole Nolen
Programs Manager, N1C
Alyssa Parker
Postdoctoral Researcher
Alex Petukhova-Greenstein
DPhil student
Archana Ramesh
DPhil Student, University of Oxford
Narjes Rohani
Postdoctoral Research Associate
Professor Stephan Sanders
MRC CoRE TG Director
Professor of Paediatric Neurogenetics, University of Oxford
Associate Professor, University of California, San Francisco (UCSF)
Dan Speckhard-Pasque
Software Developer
Shahzaib (Shaz) Tariq
DPhil Student
Professor Jenny Taylor
MRC CoRE TG Genomics Theme Lead
Professor of Translational Genomics, University of Oxford
Laura Watts
Senior Information Governance Manager
Jessica West
Postoctoral Fellow
Nicola (Nicky) Whiffin
MRC CoRE Research Culture Co-Lead
MRC CoRE Genomics Theme Co-Lead
Associate Professor and Career Development Award Fellow, University of Oxford
Emilie Wigdor
Postdoctoral Researcher, University of Oxford
Sarah Wordsworth
MRC CoRE Health Economics Lead | Professor of Health Economics, University of Oxford
Leads the Health Economics Genomics England Clinical Interpretation Partnership (GeCIP) for the UK’s 100,000 Genomes Project
Winston Yan
President, N=1 Collaborative | Co-Founder at Arbor Biotechnologies
Timothy Yu
Co-founder, N1C; Clinician Researcher, Boston Children's Hospital